William Scott is a Clinician Scientist and Investigator at Imperial College London and the MRC Laboratory of Medical Sciences. His research group studies how adipose tissues remodel in human obesity and weight loss, and how this leads to the development and remission of diabetes, by integrating findings from human tissues and experimental models. This approach has enabled them to define critical tissue injury and repair pathways linked to clinical outcomes. Building on these discoveries, they are using cell screens to identify proteins and compounds that modify these pathways, and machine learning to simulate how pathways, cells, tissues, and individual patients will respond to targeted therapeutic interventions. Ultimately, they aim to accelerate the development of new pharmacotherapies that target adipose tissues to treat diabetes and other adverse complications of obesity.